Liposome drug delivery of polycyclic, aromatic, antioxidant or anti-inflammatory compounds
AssigneeEnzRel Inc.
InventorMilton Yatvin
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Abstract
This invention comprises pharmaceutical compositions for administering a polycyclic, aromatic, antioxidant or anti-inflammatory compound to an animal. Particularly provided are proliposomal compositions that are advantageously used to deliver polycyclic, aromatic, antioxidant or anti-inflammatory compounds to the gastrointestinal tract after oral administration.
Claims39
A pharmacological composition comprising a proliposomal preparation of a polycyclic aromatic antioxidant or anti-inflammatory compound in a capsule or tablet comprising an enteric coating, and a protective coating in between the proliposomal preparation and the enteric coating, wherein the proliposomal preparation consisting essentially of one, two or three lipids, a primary aliphatic amine and cholesterol.
A method for increasing the bioavailability of a polycyclic, aromatic antioxidant or anti-inflammatory compound, said method comprising orally administering to an animal in need thereof a proliposomal preparation of a polycyclic, aromatic antioxidant or anti-inflammatory compound in a capsule or tablet comprising an enteric coating, and a protective coating in between the proliposomal preparation and the enteric coating, wherein the proliposomal preparation consisting essentially of a lipid, a primary aliphatic amine and cholesterol.
A method for delivering a polycyclic, aromatic, antioxidant or anti-inflammatory compound to the intestine or colon, said method comprising orally administering to an animal in need thereof a proliposomal preparation of a polycyclic, aromatic, antioxidant or anti-inflammatory compound in a tablet comprising an enteric coating, and a protective coating in between the proliposomal preparation and the enteric coating, wherein the proliposomal preparation consisting essentially of a lipid, a primary aliphatic amine and cholesterol.
Dependencies are inferred from the claim text.