Method and article to control cellulite

A multilayer, flexible patch configured for effecting the transdermal delivery of the skin of a human subject with an active ingredient, which ingredient is adapted for reducing the incidence of human cellulite comprising:

• (a) a pressure-sensitive, skin adherable first layer comprising an acrylate polymer substrate and theophylline dispersed therein as the active ingredient;
• (b) an outer skin conformable, backing second layer comprising a thermoplastic polyether polyurethane copolymer film;
• (c) a protective inner liner third layer which is substantially non-adhesive to the adjacent first layer comprising a silicone coated release paper or a durable cast polyester film;
• and
• (d) a supporting fourth layer, which is a silicone coated release paper or a polymeric film lightly adhering to the second layer.

A method of treating skin with an active ingredient using a multilayer patch suited for adhesion to human skin of a subject and adapted for transdermal delivery of the active ingredient to the skin adhering for an extended periods, the patch consisting:

• (a) A water vapor permeable, pressure-sensitive, skin adherable first layer containing a dispersed active ingredient, which is a compound having a xanthine structure;
• (b) an outer backing, second layer comprising a water vapor permeable, skin conformable fabric of a polymeric film adapted to provide moisture vapor permeability of the patch so as to permit transdermal moisture loss to escape therethrough;
• and,
• (c) a protective liner, third layer which is substantially, non-adhesive to the adjacent first layer and is protective of the active ingredient dispersed therein, and is adapted to be readily peeled from the patch at the time of skin application.