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AssigneeGangaGen, Inc.
InventorsJanakiraman Ramachandran, Sriram Padmanabhan, Bharathi Sriram
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The invention features incapacitated whole cell bacterial immunogenic compositions produced by infecting a bacterium with Lys minus bacteriophage, which are deficient in the lysin protein. Lys minus bacteriophage retain activity in infection of its appropriate bacterial host, destruction of the bacterial genome, and replication, which are sufficient to inhibit bacterial growth and replication. The resulting, Lys minus-infected bacterium is provided in a state of bacteriostasis, and is not capable of replicating further (e.g., is “incapacitated”). The incapacitated bacterium can then be used as to elicit an immune response for prophylactic and/or therapeutic purposes. The invention thus also features incapacitated bacteria formulated appropriately for use in immunogenic compositions for eliciting an immune response, e.g., for production of antibodies in a non-human host or in a whole cell bacterial vaccine.
A method of eliciting an immune response to a bacterial pathogen, the method comprising:
A method of vaccinating a subject against disease caused by a bacterial pathogen, the method comprising:
A method for eliciting an immune response to an antigen, the method comprising:
A composition comprising an incapacitated bacterium and a pharmaceutically acceptable excipient, wherein the incapacitated bacterium is produced by infection of a pathogenic bacterium with a lysis-defective bacteriophage.
Dependencies are inferred from the claim text.