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AssigneeOcean Nutrition Canada Limited
InventorJaroslav A. Kralovec
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Chlorella extracts containing high molecular weight Chlorella polysaccharide and polysaccharide complexes show immune modulatory, specifically immune stimulatory, activity. The polysaccharide and polysaccharide complexes contain glucose and any combination of: galactose, rhamnose, mannose and arabinose, as well as N-acetyl glucosamine and N-acetyl galactosamine. The extracts may be treated with pronase, DNAse, RNAse and proteases to remove unassociated nucleic acids, ribonucleic acids and proteins. The extracts may also undergo treatment to effect cleavage of specific glycosidic linkages, the linkages being defined by their susceptibility to cleavage by amylase, amyloglucosidase, cellulase or neuraminidase. Chlorella extracts may be administered to a mammal to increase proliferation of splenocytes and increase production of cytokines such as IL-6, IL-10, INF-γ and TNF-α. They may be used as a supplement to a vaccination regimen.
An extract comprising high molecular weight Chlorella polysaccharide and polysaccharide complexes, wherein the high molecular weight polysaccharide and polysaccharide complexes are about 1×105 Da to about 1×107 Da and constitute at least 22% (w/w) of the total Chlorella-derived content of the extract.
An extract consisting of high molecular weight Chlorella polysaccharide and polysaccharide complexes, wherein the high molecular weight polysaccharide and polysaccharide complexes are about 1×105 Da to about 1×107 Da.
A process for obtaining a Chlorella extract having immunomodulating activity, comprising:
Dependencies are inferred from the claim text.