Hla binding peptides and their uses
OwnerAlessandro Sette, John Sidneyinventors
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Abstract
The present invention provides peptide compositions capable of binding glycoproteins encoded by HLA, HLA-B, and HLA-C alleles and inducing T cell activation in T cells restricted by the HLA allele. The peptides are useful to elicit an immune response against a desired antigen.
Claims19
A composition comprising an immunogenic peptide having a supermotif which allows the immunogenic peptide to bind more than one HLA molecule, the immunogenic peptide having between about 9 and about 10 residues;
- a first conserv residue at the second position from the N-terminus being P;
- and
- a second conse ed residue at the C-terminal position being selected from the group consisting of M, I, d an aromatic residue.
7 The composition o [e in the viral host is vaccinia.
The co position of claim 1, wherein the immunogenic peptide is derived from a parasitic antig 9. The compsition of claim 8, wherein the parasitic antigen is from Plasmodium falciparum.
- 23;
- The composition of claim 9, wherein the immunogenic peptide comprises the sequence TPYAGENPAPF.
Dependencies are inferred from the claim text.