Compositions and methods for treating tumors bearing HMFG and CEA antigens
OwnerMalaya Chatterjee, Kenneth A. Fooninventors
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Abstract
The present invention provides methods and compositions for treating HMFG- and CEA-associated tumors using the anti-idiotype antibody 11D10 in conjunction with anti-idiotype antibody 3H1.
Claims58
A method of delaying development of an HMFG- and CEA-associated tumor in an individual, comprising administering an effective amount of a first antibody comprising the light and heavy chain variable region sequences contained in SEQ ID NO:2 and SEQ ID NO:4, respectively, and a second antibody comprising the light and heavy chain variable region sequences contained in SEQ ID NO:6 and SEQ ID NO:8, respectively, to the individual.
A method of treatment of an HMFG- and CEA-associated tumor in an individual comprising administering an effective amount of a first antibody comprising the light and heavy chain variable region sequences contained in SEQ ID NO:2 and SEQ ID NO:4, respectively, and a second antibody comprising the light and heavy chain variable region sequences contained in SEQ ID NO:6 and SEQ ID NO:8, respectively, to the individual.
A composition comprising a first antibody comprising the light and heavy chain variable region sequences contained in SEQ ID NO:2 and SEQ ID NO:4, respectively, and a second antibody comprising the light and heavy chain variable region sequences contained in SEQ ID NO:6 and SEQ ID NO:8, respectively.
Dependencies are inferred from the claim text.