Methods for targeting cells that express fibroblast growth receptor-3 or -2
AssigneeZymoGenetics, Inc.
InventorJames W. West
Life of this patent
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Abstract
Fibroblast growth factor-18 (FGF-18) binds with FGF receptors-2 and -3. Compositions comprising an FGF-18 component can be used to target cells that express these receptors. Suitable targets include tumor cells that express constitutively activated forms of FGF receptors-2 and -3. For example, conjugates of FGF-18 and saporin can be used to target tumor cells that express FGF receptors-2 or -3, and to inhibit the proliferation of these cells.
Claims31
An FGF-18 targeting composition, comprising an FGF-18 component and a cytotoxin.
A method of inhibiting the proliferation of cells that express fibroblast growth factor (FGF) receptor-3 or FGF receptor-2, comprising administering a composition comprising an FGF-18 targeting composition to the cells.
A composition, comprising an FGF-18 targeting composition and a carrier.
A method of inhibiting the proliferation of osteosarcoma cells, comprising administering a composition that comprises a fibroblast growth factor (FGF)-18-saporin conjugate to the osteosarcoma cells, wherein the osteosarcoma cells express at least one of FGF receptor-3 or FGF receptor-2, and wherein the FGF-18-saporin conjugate comprises the amino acid sequence of SEQ ID NO:
- 2.
A method of inhibiting the proliferation of multiple myeloma cells, comprising administering a composition that comprises a fibroblast growth factor (FGF)-18-saporin conjugate to the multiple myeloma cells, wherein the multiple myeloma cells express at least one of FGF receptor-3 or FGF receptor-2, and wherein the FGF-18-saporin conjugate comprises the amino acid sequence of SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.