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OwnerLili Yang, Luk van Parijs +1inventors
InventorsLili Yang, Luk van Parijs, David Baltimore
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The invention provides systems and methods for the generation of lymphocytes having a unique antigen specificity. In a preferred embodiment, the invention provides methods of virally infecting cells from bone marrow with one or more viral vectors that encode antigen-specific T cell receptors. The resulting lymphocytes, and in particular, T cells express the T cell receptor (TCR) that was introduced. The lymphocytes generated can be used for a variety of therapeutic purposes including the treatment of various cancers and the generation of a desired immune response to viruses and other pathogens. The resulting cells develop normally and respond to antigen both in vitro and in vivo. We also show that it is possible to modify the function of lymphocytes by using stem cells from different genetic backgrounds. Thus our system constitutes a powerful tool to generate desired lymphocyte populations both for research and therapy. Future applications of this technology may include treatments for infectious diseases, such as HIV/AIDS, cancer therapy, allergy, and autoimmune disease.
A method of generating a lymphocyte with a unique antigen specificity in a mammal comprising:
A method of stimulating an immune response to an antigen in a mammal comprising:
A method of treating cancer in a patient comprising the following steps:
A method of preventing infection in a mammal that has been or is expected to be exposed to an infectious agent comprising:
A method of producing a transgenic non-human mammal comprising lymphocytes with a unique antigen specificity comprising:
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