Methods for inhibiting histone deacetylase-4
OwnerJeffrey M. Besterman, Claire Bonfils +6inventors
InventorsJeffrey M. Besterman, Claire Bonfils, Zuomei Li, Soon Hyung Woo, Arkadii Vaisburg, Daniel Delorme, Marielle Fournel, Rico Lavoie
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Abstract
This invention relates to the inhibition of histone deacetylase (HDAC) expression and enzymatic activity. The invention provides methods and reagents for inhibiting HDAC-4 and HDAC-1 by inhibiting expression at the nucleic acid level or inhibiting enzymatic activity at the protein level.
Claims91
A method of inhibiting HDAC-4 activity in a cell, comprising contacting the cell with an antisense oligonucleotide complementary to a region of RNA that encodes a portion of HDAC-4, whereby HDAC-4 activity is inhibited.
A method of inhibiting HDAC-4 activity in a cell, comprising contacting the cell with a small molecule inhibitor of HDAC-4 selected from the group consisting of:
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A method for inhibiting neoplastic cell proliferation in an animal, comprising administering to an animal having at least one neoplastic cell present in its body a therapeutically effective amount of an antisense oligonucleotide complementary to a region of RNA that encodes a portion of HDAC-4, whereby neoplastic cell proliferation is inhibited.
A method for inhibiting neoplastic cell proliferation in an animal, comprising administering to an animal having at least one neoplastic cell present in its body a therapeutically effective amount of a small molecule inhibitor selected from the group consisting of:
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A composition comprising an agent that specifically inhibits the activity of HDAC-4.
A method for inhibiting HDAC-4 activity in a cell, comprising contacting the cell with a specific inhibitor of HDAC-4, whereby HDAC-4 activity is inhibited.
A method for inhibiting neoplastic cell proliferation in an animal, comprising administering to an animal having at least one neoplastic cell present in its body a therapeutically effective amount of at least one specific inhibitor of HDAC-4, whereby neoplastic cell proliferation is inhibited in the animal.
Dependencies are inferred from the claim text.