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US 2003/0152553 A1Published application
Compositions comprising tissue specific adenoviral vectors
AssigneeCell Genesys, Inc.
InventorsAndrew S. Little, Henry G. Lamparski, Daniel R. Henderson, Eric R. Schuur
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Abstract
Compositions comprising host cell specific adenovirus vehicles are provided for transfecting target host cells. The compositions comprise replication competent adenovirus having an adenovirus gene essential for replication under transcriptional control of a cell type specific transcriptional response element (TRE) and polyethylene glycol (PEG) as a masking agent.
Claims28
A composition comprising:
- a replication competent adenovirus having an adenovirus gene essential for replication under transcriptional control of a cell type specific transcriptional response element (TRE);
- and
- a masking agent, wherein the masking agent is polyethylene glycol (PEG).
An adenovirus, wherein proteins present in said adenovirus are covalently attached to polyethylene glycol.
Dependencies are inferred from the claim text.