Absorbable E-caprolactone polymers and medical devices
OwnerShalaby W. Shalabyinventor
Life of this patent
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Abstract
Crystalline, low melting ε-Caprolactone polymers which undergo accelerated hydrolysis, and their use as lubricant coatings and/or as coatings containing bioactive agents, as carriers of viable cells, and as coatings for open-cell microporous template or constucts for tissue regeneration; the polymers bearing basic functionalities can be linked tonically or covalently to the ester chain which induces autocatalyzed hydrolysis.
Claims10
A bioabsorbable, lubricant coating for medical devices such as surgical staples;
- facia fasteners and other surgical closure devices;
- trocars, syringes;
- endoscopes and endoscopic catheters, instruments and devices;
- surgical implants;
- vascular grafts;
- shunts;
- and stents;
- an open cell, microporous template for tissue regeneration;
- a matrix for peptides and proteins;
- a matrix for vaccines and growth factor;
- and a bioabsorbable carrier for viable cells, said coating comprising crystalline nitrogenous polyesters comprising predominantly ε-caprolactone polymer sequences linked ionically or covalently to amine-bearing structures which represent 1 to 20 percent of the total weight.
A bone wax comprising crystalline nitrogenous polyesters polymers comprising predominantly ε-caprolactone polymer sequences linked tonically or covalently to amine-bearing structures which represent 1 to 20 percent of the total weight.
A tissue sealant comprising crystalline nitrogenous polyesters polymers comprising predominantly ε-caprolactone polymer sequences linked ionically or covalently to amine-bearing structures which represent 1 to 20 percent of the total weight.
A bioabsorbable carrier as in claim 9, further comprising a growth factor.
A hemostatic agent comprising crystalline nitrogenous polyester polymers comprising predominantly ε-caprolactone polymer sequences linked ionically or covalently to amine-bearing structures which represent 1 to 20 percent of the total weight.
A component for therapeutic or prophylactic system for managing orthopedic, vascular or dental infection, said component comprising nitrogenous polyester polymers comprising predominantly ε-caprolactone polymer sequences linked ionically or covalently to amine-bearing structures which represent 1 to 20 percent of the total weight.
Dependencies are inferred from the claim text.