Mouthwash compositions
OwnerErling Johansen, Thor Olsen +1inventors
InventorsErling Johansen, Thor Olsen, Athena Papas
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Abstract
Aqueous solutions are disclosed which are supersaturated with respect to calcium phosphate(s) and which further comprise a stabilising agent in an amount sufficient to enable the calcium ions and phosphate ions to remain in supersaturated solution so that it may be used as a dental rinse or mouthwash. Such solutions are suitable for treating patients having dental caries or other conditions of the oral cavity.
Claims22
A formulation suitable for use as a dental rinse or mouthwash, which formulation comprises:
- (a) a calcium component (calcium stock solution) which itself comprises an aqueous solution of calcium ions and stabilising agent;
- and, associated therewith but separate therefrom,
- (b) a phosphate component (phosphate stock solution) which itself comprises an aqueous solution of phosphate ions and stabilising agent;
- wherein the calcium and phosphate ions are present in amounts sufficient to form, on mixing, a supersaturated solution thereof, and the amount of stabilising agent in each component is sufficient to enable the calcium and phosphate ions to remain for at least 1 minute at body temperature in supersaturated solution once components (a) and (b) are mixed.
A formulation suitable for use as a dental rinse or mouthwash, which formulation comprises:
- (a) a calcium component (calcium stock solution) which itself comprises an aqueous solution of calcium ions having a concentration in the range of from about 4 to about 80 mM and from about 40 to about 400 mM stabiliser;
- and, associated therewith but separate therefrom,
- (b) a phospate component (phosphate stock solution) which itself comprises an aqueous solution of (ortho)phosphate ions having a concentration in the range of from about 1 to about 64 mM and from about 40 to about 400 mM stabiliser
- whereby, on mixing, the components form a solution supersaturated with respect to calcium phosphate(s).
A concentrate formulation comprising:
- (a) a calcium concentrate which itself comprises an aqueous solution of calcium ions and stabilising agent;
- and, associated therewith but separate therefrom,
- (b) a phosphate concentrate which itself comprises an aqueous solution of phosphate ions and a stabilising agent
- wherein the calcium and phosphate ions and stabilising agent are present in such amounts whereby, on diluting each concentrate (a) and (b) with water and thereafter mixing the two stock solutions (a) and (b) thereby formed, there is prepared a supersaturated solution which remains so for at least 1 minute at body temperature.
A concentrate formulation comprising:
- (a) a calcium concentrate which itself comprises an aqueous solution of calcium ions in the range of from about 8 to about 2120 mM and 0M to 6.5M stabilising agent and, associated therewith but separate therefrom,
- (b) a phosphate concentrate which itself comprises an aqueous solution of phosphate ions in the range of from about 2 to about 1440 mM and from 0M to 6.5M of a stabilising agent.
A method of preparing a solution supersaturated with respect to calcium and phosphate(s) for use as an oral rinse, which solution comprises:
- calcium ions in a concentration in the range of from about 2 to about 40 mM;
- (ortho)phosphate ions in a concentration in the range of from about 0.5 to about 32 mM;
- and
- sodium ions in a concentration in the range of from 0 to about 0.5M which method comprises (a) obtaining a calcium stock solution comprising from about 4 to about 80 mM calcium ions and from about 0 to about 400 mM sodium chloride;
- (b) obtaining a phosphate stock solution comprising from about 1 to about 64 mM(ortho)phosphates and from about 0 to about 400 mM sodium chloride;
- and (c) mixing said stock solutions (a) and (b).
Dependencies are inferred from the claim text.