Bovine milk growth factor
AssigneeGropep Pty. Ltd.
InventorsAndrew Jeremy Dunbar, Christopher Goddard, David Andrew Belford
Life of this patent
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Abstract
The present invention relates to a novel growth factor from bovine milk, milk products or milk product extracts. The present invention also relates to the use of recombinant DNA technology to isolate, clone and sequence nucleic acids encoding the mature and precursor forms of the growth factor and, in addition, to the use of these nucleic acids in the recombinant production of the growth factor.
Claims11
A nucleic acid sequence encoding BMGF or a functionally active fragment thereof, wherein said nucleic acid sequence comprises the sequence shown in FIG. 5 or a sequence coding for a functionally active fragment thereof.
A method for isolating a nucleic acid sequence encoding a BMGF or a functionally active fragment thereof, comprising the steps of:
- providing a source of cells having BMGF activity;
- treating the cells to obtain mRNA therefrom;
- treating the mRNA thus obtained to produce cDNA therefrom;
- and
- amplifying the cDNA thus obtained by PCR using oligonucleotide primers to produce the nucleic acid.
A method for enhancing wound healing and/or tissue repair, comprising the step of:
- administering to a patient in need thereof an effective amount of BMGF, or mutants, analogues and derivatives of BMGF, precursor and fusion protein forms of BMGF and functionally active fragments (peptides) of BMGF.
A method for preventing or treating periodontal disease, comprising the step of:
- administering to a patient in need thereof an effective amount of BMGF, or mutants, analogues and derivatives of BMGF, precursor and fusion protein forms of BMGF and functionally active fragments (peptides) of BMGF.
A method of providing a cosmetic delivery, comprising the step of:
- administering to a subject in need thereof an effective amount of BMGF, or mutants, analogues and derivatives of BMGF, precursor and fusion protein forms of BMGF and functionally active fragments (peptides) of BMGF.
Dependencies are inferred from the claim text.