Medicinal aerosol compositions with a functionalized polyethyleneglycol excipient

A particulate medicinal composition comprising:

• particles incorporating a drug and an excipient comprising a compound of the structure R1—(O—CH2—CH2)n—X;
• wherein
• X is selected from the group consisting of:
• —C(O)OH;
• —S(O2)OH;
• —OS(O2)OH;
• —P(OH)2O;
• —OP(OH)2O;
• —N(R2)(R2);
• —OC(R2)(R2)—C(O)—Z;
• —OC(O)—R2—C(O)—Z;
• —O—R3—C(O)—Z;
• and —OC(O)CH(R3)—N(R2)(R2);
• Z is selected from —OH;
• —N(R2)(R2);
• —NH—R2—NH—;
• an amino acid residue;
• a peptide residue with from 2 to 8 amino acids;
• or a hydroxy acid;
• n is from 1 to 250;
• R1 is methyl or ethyl;
• Each R2 is independently selected from hydrogen or linear, branched, or cyclic hydrocarbon with 1 to 6 carbons;
• and
• R3 is independently selected from hydrogen or linear, branched, or cyclic hydrocarbon with 1 to 6 carbons, wherein R2 and R3 may optionally be connected together to form an alkylene bridge of from 2 to 4 carbons;
• wherein the particles have a mass mean aerodynamic diameter of less than about 10 microns.

An aqueous medicinal composition comprising:

• an aqueous carrier fluid;
• an excipient comprising a compound of the structure R1—(O—CH2—CH2)n—X;
• wherein
• X is selected from the group consisting of:
• —C(O)OH;
• —S(O2)OH;
• —OS(O2)OH;
• —P(OH)2O;
• —OP(OH)2O;
• —N(R2)(R2);
• —OC(R2)(R2)—C(O)—Z;
• —OC(O)—R2—C(O)—Z;
• —O—R3—C(O)—Z;
• and —OC(O)CH(R3)—N(R2)(R2);
• Z is selected from —OH;
• —N(R2)(R2);
• —NH-R2—NH—;
• an amino acid residue;
• a peptide residue with from 2 to 8 amino acids;
• or a hydroxy acid;
• n is from 1 to 250;
• R1 is methyl or ethyl;
• Each R2 is independently selected from hydrogen or linear, branched, or cyclic hydrocarbon with 1 to 6 carbons;
• and
• R3 is independently selected from hydrogen or linear, branched, or cyclic hydrocarbon with 1 to 6 carbons, wherein R2 and R3 may optionally be connected together to form an alkylene bridge of from 2 to 4 carbons;
• and
• a drug.