Methods for cancer imaging
AssigneeThreshold Pharmaceuticals, Inc.
InventorsGeorge Tidmarsh, Mark Matteucci
Life of this patent
Estimating the term…
Abstract
Methods are provided for cancer and pre-cancer detection by increased uptake of fluorophore glucose or deoxyglucose conjugates in cancerous and pre-cancerous cells relative to normal cells.
Claims20
A method for detecting or imaging cancer in a subject, said method comprising:
- (a) administering to said subject an effective amount of a fluorophore glucose, deoxyglucose or derivative conjugate;
- and
- (b) detecting or imaging cells that take up said fluorophore conjugate to determine if cancer is present in said subject.
A method of detecting pre-cancerous cells in a subject, said method comprising:
- (a) administering to said subject an effective amount of a fluorophore glucose or deoxyglucose conjugate;
- and
- (b) detecting or imaging pre-cancer cells that take up said fluorophore conjugate to determine if pre-cancer cells are present in said subject.
A fluorophore conjugate having the formula:
- Fl-L-Glc
- wherein
- Fl is a fluorophore having an emission wavelength of from about 400 nm to about 1200 nm;
- L is a bond or a linking group;
- and
- Glc is glucose, deoxyglucose or a glucose or deoxyglucose derivative, with the proviso that said fluorophore deoxyglucose conjugate is other than 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose.
A method for cancer or pre-cancer detection during an operative or endoscopic procedure, said method comprising:
- (a) administering to a patient subject to said procedure, an effective amount of a fluorescent glucose or deoxyglucose conjugate, said conjugate having a rate of uptake in cancerous or pre-cancerous cells that is at least two times greater than the rate of uptake in normal cells;
- (b) conducting said procedure within 48 hours of said administering;
- (c) scanning said patient with a detection means for detecting the localization of said fluorescent conjugate in said cancer or pre-cancer cells.
A kit comprising a vial containing a sterile preparation for human use of a fluorophore glucose, deoxyglucose or derivative conjugate and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.