Method for estimating effective regimens and patient survival rates of antibiotic treatments for fatal infectious diseases
OwnerRen-Jin Leeinventor
Life of this patent
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Abstract
The present invention relates to a method for estimating effective regimens and patient survival rates of antibiotic treatments for fatal infectious diseases. More particularly, the invention estimates the effective dose regimens and the patient survival rate, utilizing (1) the survival data of patients receiving either no treatment or inactive treatments and (2) the correlation between the organism eradication rate and the dose regimen of the antibiotics.
Claims15
Methods for estimating the survival rate or mortality rate of patients with a fatal infectious disease following an antibiotic treatment, said methods comprising:
- (a) determining the survival rate or the mortality rate of controlled patients with the same disease, said controlled patients receiving no treatment, or receiving placebo or an inactive treatment;
- (b) determining a correlation between (1) the organism eradication rate of said antibiotic and (2) the dose regimen of said antibiotic;
- (c) estimating the survival rate or the mortality rate of the antibiotic-treated patients based on (1) the survival rate or the mortality rate of the controlled patients, and (2) the organism eradication rate.
Methods for providing evidence to support an effective dosing regimen of an antibiotic for treating a fatal infectious disease using the estimated survival rate or mortality rate of said patients, said methods comprising:
- (a) determining the survival rate or the mortality rate of controlled patients with the same disease, said controlled patients receiving no treatment, or receiving placebo or an inactive treatment;
- (b) determining a correlation between (1) the organism eradication rate of said antibiotic and (2) the dose regimen of said antibiotic;
- (c) estimating the survival rate or the mortality rate of the antibiotic-treated patients based on (1) the survival rate or the mortality rate of the controlled patients, and (2) the organism eradication rate;
- (d) determining the effective dose regimen of said antibiotic by targeting the survival rate or mortality rate of the antibiotic-treated patients.
Dependencies are inferred from the claim text.