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US 2003/0152513 A1Published application
Intravascular delivery of therapeutic and imaging agents to stressed and apoptotic cells using annexin V as a targeting vector
AssigneeImetrix, Inc.
InventorsFrancis G. Blankenberg, Jagat Narula, H. William Strauss, Vartan Ghazarossian
Life of this patent
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Abstract
The present invention relies on the affinity of stressed or apoptotic cells for exogenously administered annexin V to create a multi-functional molecular probe that can be simultaneously used for imaging (localization of unstable plaque within the body) and therapy (treatment of unstable plaque).
Claims10
Compositions for detecting and treating vulnerable plaque, said compositions comprising:
- a binding molecule which specifically binds to markers on stressed or apoptotic cells which are characteristic of vulnerable plaque;
- a targeting molecule coupled to the binding molecule which permits localization of the composition when intravascularly bound to vulnerable plaque;
- and
- an effector molecule coupled to the binding molecule which selectively kills or inhibits the stressed or apoptotic cells.
1 more element
Compositions for detecting and treating vulnerable plaque, said compositions comprising:
- an annexin;
- and
- a targeting molecule coupled to the annexin which permits localization of the composition when intravascularly bound to vulnerable plaque.
A method for detecting and treating vulnerable plaque, said method comprising:
- administering a composition to a patient suspected of having vulnerable plaque, said composition being capable of specifically binding to the vulnerable plaque, being localized when bound, and killing or inhibiting the apoptotic or stressed cells characteristic of vulnerable plaque;
- determining whether the composition has localized within the vasculature, and
- activating the composition to kill or inhibit the apoptotic or stressed cells the composition has localized.
Dependencies are inferred from the claim text.