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US 2003/0152500 A1Published application
Rotor-stator apparatus and process for the formation of particles
OwnerSean Mark Dalziel, Erik Henricus Jacobus Cornelis Gommeren +2inventors
InventorsSean Mark Dalziel, Erik Henricus Jacobus Cornelis Gommeren, Richard V. Calabrese, Thomas E. Friedmann
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Abstract
The present invention relates to the use of a high intensity, in-line rotor-stator apparatus to produce fine particles via antisolvent, reactive, salting out or rapid cooling precipitation and crystallization.
Claims36
A crystallization/precipitation apparatus comprising:
- a housing having at least a first cavity;
- a stator having a plurality of apertures, an interior wall portion, and an outer wall portion, wherein the stator resides within the first cavity;
- a rotor, wherein the rotor is connected to a rotatably mounted drive shaft and is contained within a rotor-swept volume;
- at least two inlet pipes, wherein the at least two inlet pipes introduce at least two fluid streams into the rotor-swept volume;
- at least one entry port;
- and an outlet orifice.
3 more elements
A crystallization/precipitation apparatus comprising:
- a stainless steel housing having a first cavity and a second cavity;
- a stainless steel cylindrical stator having a plurality of apertures, an interior wall portion, and an outer wall portion, wherein the stator resides within the first cavity;
- a stainless steel rotor having at least one radially extending blade and at least one blade tip that is separated from the interior wall portion of the stator by a shear gap of about 1 mm, wherein the rotor is connected to a rotatably mounted drive shaft that extends through the second cavity and is contained within a rotor-swept volume;
- at least two multi-axial inlet pipes, wherein the at least two multi-axial inlet pipes introduce at least two fluid streams into the rotor-swept volume;
- at least one entry port;
- and an outlet orifice.
3 more elements
A process for crystallizing/precipitating particles comprising the steps of:
- feeding at least two fluids into a rotor-stator apparatus, wherein at least one first fluid is a solvent comprising at least one dissolved substance that is to be precipitated into particles and at least one second fluid comprising an anti-solvent, said solvent and anti-solvent being miscible;
- mixing said first and second fluids using a shear force in a high shear zone wherein the at least one dissolved substance is caused to crystallize/precipitate into particles from said first solution on being mixed with said second fluid in the high shear zone;
- and causing the mixed first and second fluids and the particles to exit the rotor-stator apparatus.
Dependencies are inferred from the claim text.