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US 2003/0152491 A1Published application
Bidirectional flow centrifugal microfluidic devices
AssigneeTecan Trading AG
InventorsGregory J. Kellogg, Bruce L. Carvalho
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Abstract
This invention relates to methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. The invention particularly provides microsystem platforms for achieving efficient mixing of one or a plurality of fluids on the surface of the platform when fluid flow is motivated by centripetal force produce by rotation.
Claims5
A centripetally-motivated microsystems platform comprising:
- a) a rotatable platform comprising a substrate having an axis of rotation and a surface comprising one or a multiplicity of microfluidics structures embedded in the surface of the platform, wherein each microfluidics structure comprises
- i) one or a plurality of fluid reservoirs,
- ii) one or a plurality of detection chambers,
- iii) one or a plurality of mixing microchannels
- wherein the interior surface of each of the microchannels comprises a graded hydrophobic surface, wherein the hydrophobicity of the surface increases with distance from the axis of rotation, and wherein each of said fluid reservoir is fluidly connected to a mixing microchannel that is fluidly connected to a detection chamber, and wherein fluid within the microchannels of the platform is moved through said microchannels by centripetal force arising from rotational motion of the platform for a time and a rotational velocity sufficient to move the fluid through the microchannels.
2 more elements
A centripetally-motivated microsystems platform comprising:
- a) a rotatable platform comprising a substrate having an axis of rotation and a surface comprising one or a multiplicity of microfluidics structures embedded in the surface of the platform, wherein each microfluidics structure comprises
- i) one or a plurality of fluid reservoirs,
- ii) one or a plurality of detection chambers,
- iii) one or a plurality of mixing microchannels
- wherein the interior surface of each of the microchannels comprises a graded surface to volume ratio, wherein the surface to volume ratio increases with distance from the axis of rotation, and wherein each of said fluid reservoir is fluidly connected to a mixing microchannel that is fluidly connected to a detection chamber, and wherein fluid within the microchannels of the platform is moved through said microchannels by centripetal force arising from rotational motion of the platform for a time and a rotational velocity sufficient to move the fluid through the microchannels.
2 more elements
Dependencies are inferred from the claim text.