Device and a method for thermal sensing

A method for detecting an effect of a cell affecting agent on a cell comprising:

• providing a device, said device comprising a support;
• a membrane having a first surface and a second surface, said membrane mechanically supported by said support on at least one point on one of said first surface or said second surface,
• at least one pair of devices, wherein one device of said pair of devices is located in a first region of said first surface of said membrane and the other device of said pair of devices is located in a second region of said first surface of said membrane, wherein said membrane thermally and electrically isolates said first region and said second region, and wherein each device of said pair of devices yields an electrical output signal in response to having an input signal of the thermal type,
• a first supply for bringing a first substance in thermal contact with said first region, and
• a second supply for bringing a second substance in thermal contact with said second region, wherein said first substance is separated and thermally isolated from said second substance;
• providing reference cells in said first region;
• providing genetically modified cells in said second region, said genetically modified cells expressing a cell affecting agent target;
• contacting said cells in the first region and the second region with said cell affecting agent;
• and
• determining whether there is a relative heat change in said second region.