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US 2003/0150987 A1Published application
FAIMS with non-destructive detection of selectively transmitted ions
AssigneeIonalytics Corporation
InventorsRoger Guevremont, Randy Purves, David Barnett
Life of this patent
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Abstract
Disclosed is a high field asymmetric waveform ion mobility spectrometer (FAIMS) with optical based detection of selectively transmitted ions. Light from a light source is directed through an optical port in an electrode of the FAIMS. A light detector is provided for receiving light that is one of transmitted and scattered by the selectively transmitted ions within the FAIMS.
Claims38
An apparatus for separating ions in the gas phase, comprising:
- a high field asymmetric waveform ion mobility spectrometer comprising two electrodes defining an analyzer region therebetween, the two electrodes disposed in a spaced apart arrangement for allowing ions to propagate therebetween and for providing an electric field within the analyzer region resulting from the application of an asymmetric waveform voltage to at least one of the two electrodes and from the application of a compensation voltage to at least one of the two electrodes, for selectively transmitting a first ion type in the analyzer region at a given combination of asymmetric waveform voltage and compensation voltage;
- and,
- a probe signal generator for generating a probe signal which when applied to the selectively transmitted ions results in light including information relating to the selectively transmitted ions within the analyzer region.
An apparatus for separating ions in the gas phase, comprising:
- a high field asymmetric waveform ion mobility spectrometer comprising two electrodes defining an analyzer region therebetween, the two electrodes disposed in a spaced apart arrangement for allowing a gas flow to pass therebetween and for providing an electric field within the analyzer region resulting from the application of an asymmetric waveform voltage to at least one of the two electrodes and from the application of a compensation voltage to at least one of the two electrodes, for selectively transmitting a first ion type in the analyzer region at a given combination of asymmetric waveform voltage and compensation voltage, whereby, in use, the asymmetric waveform voltage, the compensation voltage and the gas flow are adjustable, so as to confine some of the selectively transmitted ions within a 3-dimensional region of space within the analyzer region;
- a first optical port disposed within a surface of one of the two electrodes and adjacent to a portion of the analyzer region including the 3-dimensional region of space;
- and,
- a light source disposed external to the analyzer region and in optical communication with the first optical port for providing incident light having a wavelength within a predetermined range of wavelengths to the selectively transmitted ions within the 3-dimensional region of space.
1 more element
A method for separating ions in the gas phase, comprising the steps of:
- separating a mixture of ions including ions of a first type by selectively transmitting the ions of the first type through an analyzer region of a high field asymmetric waveform ion mobility spectrometer along an ion flow path between an ion inlet end of the analyzer region and an ion outlet end of the analyzer region;
- providing a stimulus to the selectively transmitted ions within at least a portion of the analyzer region for producing light including information relating to the selectively transmitted ions;
- and
- providing the light including information relating to the selectively transmitted ions to a light detector that is external to the analyzer region.
1 more element
A method for separating ions in the gas phase, comprising the steps of:
- separating a mixture of ions including ions of a first type by selectively transmitting the ions of a first type through an analyzer region of a high field asymmetric waveform ion mobility spectrometer along an ion flow path between an ion inlet of the analyzer region and an ion outlet of the analyzer region;
- confining some of the selectively transmitted ions within a 3-dimensional region of space adjacent to the ion outlet and within the analyzer region;
- directing incident light through the 3-dimensional region of space adjacent to the ion outlet and within the analyzer region for interacting with the selectively transmitted ions within the 3-dimensional region of space adjacent to the ion outlet and within the analyzer region;
- and,
- detecting light including information relating to the selectively transmitted ions resulting from an interaction between the incident light and the selectively transmitted ions confined within the 3-dimensional region of space adjacent to the ion outlet and within the analyzer region.
2 more elements
A method for separating ions in the gas phase, comprising the steps of:
- effecting a first separation of the ions within a portion of an analyzer region between an ion inlet end of the analyzer region and a reaction portion of the analyzer region;
- affecting the ions within the reaction portion of the analyzer region so as to induce a structural change of the ions;
- and,
- effecting a second separation of the ions within a portion of an analyzer region between the reaction portion of the analyzer region and an ion outlet end of the analyzer region.
1 more element
Dependencies are inferred from the claim text.