FAIMS with non-destructive detection of selectively transmitted ions

An apparatus for separating ions in the gas phase, comprising:

• a high field asymmetric waveform ion mobility spectrometer comprising two electrodes defining an analyzer region therebetween, the two electrodes disposed in a spaced apart arrangement for allowing a gas flow to pass therebetween and for providing an electric field within the analyzer region resulting from the application of an asymmetric waveform voltage to at least one of the two electrodes and from the application of a compensation voltage to at least one of the two electrodes, for selectively transmitting a first type of ion along an average ion flow path within the analyzer region between an origin of the ion flow path and an ion outlet orifice of the analyzer region at a given combination of asymmetric waveform voltage and compensation voltage, whereby, in use, at least one of the asymmetric waveform voltage, the compensation voltage and the gas flow are adjustable, so as to confine some of the selectively transmitted ions within a 3-dimensional region of space within the analyzer region and adjacent to the ion outlet orifice;
• and,
• a first optical port disposed within a surface of one of the two electrodes and adjacent to the analyzer region at a point that is generally aligned with the 3-dimensional region of space within the analyzer region and adjacent to the ion outlet orifice, the first optical port formed of a material other than a gas, which material is transmissive to light within a predetermined range of wavelengths for propagating light including information relating to the selectively transmitted ions therethrough.

An apparatus for separating ions in the gas phase, comprising:

• a high field asymmetric waveform ion mobility spectrometer comprising two electrodes defining an analyzer region therebetween, the two electrodes disposed in a spaced apart arrangement for allowing a gas flow to pass therebetween and for providing an electric field within the analyzer region resulting from the application of an asymmetric waveform voltage to at least one of the two electrodes and from the application of a compensation voltage to at least one of the two electrodes, for selectively transmitting a first ion type in the analyzer region at a given combination of asymmetric waveform voltage and compensation voltage, whereby, in use, at least one of the asymmetric waveform voltage, the compensation voltage and the gas flow are adjustable, so as to confine some of the selectively transmitted ions within a 3-dimensional region of space within the analyzer region;
• a first optical port disposed within a surface of one of the two electrodes and adjacent to a portion of the analyzer region including the 3-dimensional region of space, the first optical port for propagating incident light along an optical path including the first optical port and the 3-dimensional region of space;
• and,
• a second optical port disposed within a surface of one of the two electrodes and adjacent to the portion of the analyzer region including the 3-dimensional region of space, the second optical port for propagating other light, resulting from the passage of the incident light through the 3-dimensional region of space, therethrough.