Novel parallel throughput system
OwnerIrving Wainer, Ruin Moaddelinventors
Life of this patent
Estimating the term…
Abstract
The present invention relates to a novel parallel throughput system that permits simultaneous screening of compounds in different modules of the system. Each module comprises a support having at least one species of protein binding moiety either immobilized through a covalent bond with the support surface to form an immobilized protein binding moiety or non-covalently immobilized in a stationary phase such that the tertiary structure of the protein in either immobilized binding moiety permits specific binding to a molecule that is bound by said protein in said immobilized binding moiety, and at least one marker molecule associated with the protein binding moiety species.
Claims21
A parallel throughput system comprising at least one module, said module comprising:
- a) a plurality of chromatography columns, wherein each column comprises a support having at least one species of protein binding moiety either (1) immobilized through a covalent bond with the support surface to form an immobilized protein binding moiety or (2) noncovalently immobilized in a stationary phase such that the tertiary structure of the protein in either immobilized binding moiety permits specific binding to a molecule that is bound by said protein in said immobilized binding moiety, and
- b) an injector for distributing a sample into the plurality of columns.
A method of using parallel throughput system having at least one module, said module comprising a plurality of chromatography columns, wherein each column comprises a support having at least one species of protein binding moiety either (1) immobilized through a covalent bond with the support surface to form an immobilized protein binding moiety or (2) non-covalently immobilized in a stationary phase such that the tertiary structure of the protein in either immobilized binding moiety permits specific binding to a molecule that is bound by said protein in said immobilized binding moiety, and an injector for distributing a sample into the plurality of columns, said method comprising:
- a) placing a sample into said module;
- and
- b) injecting said sample into said plurality of columns.
A method for performing drug discovery utilizing a parallel throughput system having at least one module, said module comprising a plurality of chromatography columns, wherein each column comprises a support having at least one species of protein binding moiety either (1) immobilized through a covalent bond with the support surface to form an immobilized protein binding moiety or (2) non-covalently immobilized in a stationary phase such that the tertiary structure of the protein in either immobilized binding moiety permits specific binding to a molecule that is bound by said protein in said immobilized binding moiety, and an injector for distributing a sample into the plurality of columns, said method comprising:
- a) analyzing a sample with said system in a process of lead optimization.
Dependencies are inferred from the claim text.