Aerosolization apparatus with removable mouthpiece

An aerosolization apparatus comprising:

• a body having an inlet;
• an endpiece having an outlet, the endpiece being connectable to the body to define a chamber, wherein the chamber is sized to receive a capsule containing a pharmaceutical formulation in a manner which allows the capsule to move within the chamber;
• a connection mechanism to provide selective connection of the endpiece to the body, wherein the connection mechanism comprises engageable threads;
• and
• a puncturing mechanism capable of providing an opening in the capsule;
• whereby when a user inhales, air enters into the chamber through the inlet so that the pharmaceutical formulation is aerosolized within the chamber and the aerosolized pharmaceutical formulation is delivered to the user through the outlet.

An aerosolization apparatus comprising:

• a body having an inlet;
• an endpiece having an outlet, the endpiece being connectable to the body to define a chamber, wherein the chamber is sized to receive a capsule containing a pharmaceutical formulation in a manner which allows the capsule to move within the chamber;
• a connection mechanism to provide selective connection of the endpiece to the body, wherein the connection mechanism comprises a protrusion that is receivable within a slot, the slot comprising a longitudinally extending portion and a transversely extending portion;
• and
• a puncturing mechanism capable of providing an opening in the capsule;
• whereby during inhalation air enters into the chamber through the inlet so that the pharmaceutical formulation is aerosolized within the chamber and the aerosolized pharmaceutical formulation is delivered to the user through the outlet.

A method of aerosolizing a pharmaceutical formulation, the method comprising:

• inserting a capsule containing a pharmaceutical formulation into a chamber in a body;
• rotating an endpiece relative to the body to connect the endpiece to the body, the rotation being about an axis passing through the chamber;
• before, during, or after inserting the capsule into the chamber, providing an opening in the capsule;
• and
• inhaling through an opening in the endpiece to cause air to flow into the chamber through an inlet in the body thereby aerosolizing the pharmaceutical formulation.