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US 2003/0150085 A1Published application
Manipulation of solvent properties for particle formation
OwnerLalit Chordia, Poongunran Muthukumaraninventors
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Abstract
Present invention provides method and apparatus to produce fine particles of a desired substance utilizing antisolvent precipitation technique. It further provides ways to manipulate the solvent and antisolvent to obtain fine particles of desired characteristics.
Claims14
A method and apparatus for manufacture of particles of a desired substance comprising:
- a. Using a solvent in which the desired substance has no or negligible solubility at ambient conditions.
- b. Manipulating pressure and temperature of said solvent to increase the solubility of said desired substance.
- c. Using an antisolvent such that:
- 1) Desired substance has minimal solubility in said antisolvent both at ambient and manipulated conditions.
- 2) Solvent is reasonably miscible with said antisolvent at manipulated conditions.
- d. Applying a dispersion having at least a desired solvent and the desired substance into a vessel.
- e. Applying an antisolvent at a high desired temperature and high desired pressure to the dispersion continuously.
4 more elements
Dependencies are inferred from the claim text.