Loading patent…
OwnerJose Ramon Botella Mesa, Michael Wayne Graham +1inventors
InventorsJose Ramon Botella Mesa, Michael Wayne Graham, David James Fairbairn
Estimating the term…
Methods are provided for the genetic control of pathogen infestation in host organisms such as plants, vertebrate animals and fungi. Such methods utilize the host as a delivery system for the delivery of genetic agents, preferably in the form of RNA molecules, to a pathogen, which agents cause directly or indirectly an impairment in the ability of the pathogen to maintain itself, grow or otherwise infest a host plant, vertebrate animal or fungus. Also provided are DNA constructs and novel nematode nucleotide sequences for use in same, that facilitate pathogen resistance when expressed in a genetically-modified host. Such constructs direct the expression of RNA molecules substantially homologous and/or complementary to an RNA molecule encoded by a nucleotide sequence within the genome of a pathogen and/or of the cells of a host to effect down-regulation of the nucleotide sequence. Particular hosts contemplated are plants, such as pineapple plants, and particular pathogens are nematodes.
A method for facilitating host resistance to at least one pathogen, said method including the step of generating a host which comprises one or more nucleotide sequences that is/are transcribable to one or more respective RNA molecules and that is/are substantially homologous and/or complementary to one or more respective nucleotide sequences of the genome of said at least one pathogen, such that upon exposure of said at least one pathogen to said host, there is down-regulation of expression of at least one of said respective nucleotide sequences of the genome of said at least one pathogen which thereby facilitates host resistance to said pathogen.
A genetic construct for facilitating host resistance to a pathogen, said genetic construct comprising one or more nucleotide sequences that is/are transcribable to an RNA molecule and that is/are substantially homologous and/or complementary to one or more nucleotide sequences encoded by the genome of said pathogen, such that upon exposure of said pathogen to one or more RNA molecules transcribed from said one or more nucleotide sequences, there is down-regulation of expression of at least one of said respective nucleotide sequences of the genome of said pathogen.
A genetic construct for facilitating host resistance to a pathogen, said genetic construct comprising one or more nucleotide sequences selected from the group consisting of:
A method for facilitating pineapple plant resistance to nematode infection and/or infestation, said method including the step of generating a pineapple plant which comprises one or more nucleotide sequences that is/are transcribable to one or more respective RNA molecules and that is/are substantially homologous and/or complementary to one or more respective nucleotide sequences of the genome of said nematode, such that upon exposure of said nematode to said pineapple plant comprising said one or more respective RNA molecule(s), there is down-regulation of expression of at least one of said respective nucleotide sequences of the genome of said nematode which thereby facilitates nematode resistance of said pineapple plant.
Dependencies are inferred from the claim text.