Gene transfer in poultry by introduction of embryo cells in ovo
OwnerJames Petitte, Catherine A. Ricks +1inventors
InventorsJames Petitte, Catherine A. Ricks, Sally E. Spence
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Abstract
A method of altering the phenotype of a bird comprises introducing a DNA sequence into somatic cells of a bird contained within an egg during in ovo incubation. The DNA sequence is selected to be effective to cause a change in phenotype, such as an increase in growth rate, feed efficiency, or both in the bird after hatch. A DNA sequence may further be selected to increase disease resistance or induce disease prevention by the expression of an antigen over a period of time.
Claims32
A method of altering the phenotype of a bird, comprising introducing avian somatic tissue-specific stem cells into an egg containing a bird during in ovo incubation, said cells containing and capable of expressing at least one DNA molecule in an amount effective to cause a change in the phenotype of the bird.
A method according to claim 11, further comprising the step of raising said bird to at least an age at which said change in phenotype is expressed.
A method of altering the phenotype of a bird comprising introducing avian embryo cells into the air cell of an egg containing a bird during in ovo incubation, said embryo cells containing and capable of expressing at least one DNA molecule in an amount effective to cause a change in the phenotype of the bird.
A method of altering the phenotype of a bird comprising introducing avian somatic tissue-specific stem cells to the air cell of an egg containing a bird during in ovo incubation, the avian somatic tissue-specific stem cells containing and capable of expressing at least one DNA molecule in an amount effective to cause a change in the phenotype of the bird.
A method according to claim 32, further comprising the step of raising said bird to at least an age at which said change in phenotype is expressed.
Dependencies are inferred from the claim text.