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US 2003/0149995 A1Published application
Compound screening methods
AssigneeDevgen NV
InventorsRichard Zwaal, Jose Groenen, Thierry Bogaert
Life of this patent
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Abstract
The invention provides methods of screening for compounds which affect the activity of a physiologically important calcium pump, the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), using the nematode worm C. elegans.
Claims20
A method of identifying compounds which modulate the interaction between a sarco/endoplasmic reticulum calcium ATPase and phospholamban, which method comprises:
- exposing transgenic C. elegans which contains a first transgene comprising nucleic acid encoding a vertebrate phospholamban protein and which expresses a SERCA protein to a compound under test;
- and
- detecting a phenotypic, biochemical or behavioural change in the transgenic C. elegans indicating an increase in the activity of the SERCA protein.
Dependencies are inferred from the claim text.