Method for matching molecular spatial patterns

A method of identifying similar molecular sequences comprising:

• a) generating a plurality of comparison metrics by comparing a first identified subsequence with a plurality of identified subsequences wherein the subsequences consist of groups of atoms associated with surface motifs of a plurality of molecular sequences;
• b) calculating the statistical significance of at least one of the comparison metrics;
• c) identifying molecular sequences that are similar to the molecular sequence corresponding to the first identified subsequence based on the statistical significance of the comparison metrics;
• and
• d) generating a plurality of geometric comparison metrics of the first identified subsequence with a plurality of identified subsequences corresponding to the statistically significant comparison metrics.

A method of identifying similar surface motifs of molecular sequences comprising:

• a identifying surface motifs of a plurality of molecular sequences;
• b identifying subsequences consisting of groups of atoms from the molecular sequences associated with the surface motifs;
• c generating a plurality of comparison metrics by comparing a first identified subsequence with a plurality of identified subsequences;
• and
• d identifying molecular sequences that are similar to the molecular sequence corresponding to the first identified subsequence based on the comparison metrics.