Coated vascular prosthesis and methods of manufacture and use

A method for sealing the pores of a fabric graft comprising the steps of:

• applying a first solution to a first surface of the graft, the first solution comprising a polyurethane and a salt in a first solvent;
• allowing the first solution to dry, thereby forming a first coat on the graft;
• applying a second solution to the coated first surface, the second solution comprising a second polyurethane in a second solvent;
• and
• immersing the coated graft in water to precipitate the second polyurethane from solution, thereby forming a porous second coat, and dissolving the salt in the first coat to form pores in the first coat.

A vascular prosthesis comprising:

• a substrate comprising a crimped woven or knitted polymer fabric, the substrate having a first surface and a second surface opposite the first surface, the second surface being a blood interface surface;
• a first porous coating disposed on the first surface, the first porous coating comprising a first polymer;
• and
• a second porous coating disposed on the first porous coating, the second porous coating comprising a second polymer, and wherein the first coating does not penetrate to the second surface of the substrate.

A vascular prosthesis comprising:

• a first layer comprising a crimped woven or knitted polymer fabric having a first surface;
• a second layer comprising a first porous coating disposed on the first surface, the first porous coating comprising a first polymer;
• and
• a third layer comprising a second porous coating disposed on the first porous coating, the second porous coating comprising a second polymer, and wherein the second layer is disposed between the first and third layers, and wherein the first porous coating does not penetrate to a second surface of the first layer.

A method for providing cardiac support in an individual comprising implanting a ventricular assist device in the individual, the ventricular assist device comprising an outflow graft, the outflow graft comprising:

• a substrate comprising a crimped woven or knitted polymer fabric, the substrate having a first surface and a second surface opposite the first surface, the second surface being a blood interface surface;
• a first porous coating disposed on the first surface, the first porous coating comprising a first polymer;
• and
• a second porous coating disposed on the first porous coating, the second porous coating comprising a second polymer, and wherein the first coating does not penetrate to the second surface of the substrate.

A method for repairing a defective vessel in an individual comprising reinforcing or replacing the defective vessel with a vascular graft comprising:

• a substrate comprising a crimped woven or knitted polymer fabric, the substrate having a first surface and a second surface opposite the first surface, the second surface being a blood interface surface;
• a first porous coating disposed on the first surface, the first porous coating comprising a first polymer;
• and
• a second porous coating disposed on the first porous coating, the second porous coating comprising a second polymer, and wherein the first coating does not penetrate to the second surface of the substrate.