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US 2003/0149307 A1Published application
Process for the preparation of polyethylene glycol bis amine
AssigneeBaxter International Inc.
InventorsTon That Hai, Larry J. Markoski, David E. Pereira, Mark Nordhaus
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Abstract
A two step process for the preparation of polyethylene glycol-bis amine comprising a first step of reacting the terminal hydroxy groups of polyethylene glycol with a halogen substituted aromatic sulfonyl halide in a solvent to form a disubstituted sulfonyl activated polyethylene glycol intermediate. In a second step the intermediate is directly aminated with ammonia to give polyethylene glycol-bis amine.
Claims20
A process for the preparation of an amino polyethylene glycol, the process comprising:
- reacting a polyethylene glycol and an aromatic sulfonyl halide substituted with at least one electron-withdrawing group in at least one solvent to form an intermediate;
- and
- aminating said intermediate to form said amino polyethylene glycol.
Dependencies are inferred from the claim text.