Process for the preparation of polymorph of 4-(aryl)-1,2,3,4-tetrahydro-1-naphthale-namine derivative
OwnerTrinadha Rao Chitturi, Rajamannar Thennatiinventors
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Abstract
A process for the preparation of a polymorph of 4-(aryl)-1,2,3,4-tetrahydro-1-naphthalenamine derivative, a hydrochloride salt of (1S,4S) N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine, comprising adding hydrochloride salt of (1S,4S) N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine to an alkanol-water solvent system, heating to dissolve and cooling the solution to allow crystallization to occur so as to obtain Form V.
Claims8
A process for the preparation of a polymorphy of hydrochloride salt of (1S, 4S) N-methyl-4-(3,4,-dichlorophenyl)-1,2,3,4tetrahydro-1-naphthalenamine, comprising adding the hydrochloride salt of (1S,4S) N-methyl-4-dichlorophenyl-1,2,3,4-tetrahydro-1-napthalanamino to an alkanol-water solvent system containing a polyol selected from glycerol, mannitol, sorbitol, inositol, xylitol, 1,3-butanediol and 1,2-propanediol, heating to dissolve and cooling the solution to allow crystallization to occur so as to obtain Form V.
Dependencies are inferred from the claim text.