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US 2003/0149279 A1Published application
Process for the production of amorphous atorvastatin calcium
OwnerYatendra Kumar, Rajesh Kumar Thaper +1inventors
InventorsYatendra Kumar, Rajesh Kumar Thaper, S. M. Dileep Kumar
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Abstract
A process for the preparation of amorphous atorvastatin calcium and hydrates thereof which comprises: (a) dissolving crystalline atorvastatin calcium in a non-hydroxylic solvent; (b) adding a non-polar hydrocarbon anti-solvent or adding the dissolved atorvastatin to the non-polar anti-solvent to precipitate out atorvastatin calcium; and (c) removing the solvent by filtration to afford amorphous atorvastatin calcium.
Claims6
A process for the preparation of amorphous atorvastatin calcium and hydrates thereof which comprises:
- (a) dissolving crystalline atorvastatin calcium in a non-hydroxylic solvent;
- (b) adding a non-polar hydrocarbon anti-solvent or adding the dissolved atorvastatin to the non-polar anti-solvent to precipitate out atorvastatin calcium;
- and
- (c) removing the solvent by filtration to afford amorphous atorvastatin calcium.
1 more element
Dependencies are inferred from the claim text.