Substituted piperidine derivatives

A compound of formula (I)

• 7
• wherein R1 is benzothienyl, benzofuranyl, naphthyl (where the benzothienyl, benzofuranyl or naphthyl moiety may be optionally substituted by one or more substituents selected from halogen, C1-6alkyl, C3-6cycloalkyl, C1-6alkoxy and C2-6alkenyl), substituted-thienyl or substituted-furanyl (where the thienyl or furanyl moiety is substituted by one or more substituents selected from halogen, C1-6alkyl, C3-6cycloalkyl, C1-6alkoxy and C2-6alkenyl);
• R2 is substituted-phenyl or substituted-thienyl (where the phenyl or thienyl moiety is substituted by one or more substituents selected from C1-6alkyl and halogen);
• R3 is —(CH2)mXCONR4R5 or —(CH2)mNR6COR7 wherein R4 is hydrogen or C1-6alkyl and R5 is hydrogen, C1-6alkyl, C3-6cycloalkyl, C6-12aryl, C6-12aryl-C1-6alkyl or a C3-9heterocyclic group (where the alkyl, aryl or heterocyclic moiety may be optionally substituted by one or more substituents selected from halogen, C1-6alkyl, C3-6cycloalkyl, C1-6alkoxy and C2-6alkenyl) or R4 and R5 together with the nitrogen atom to which they are attached form a 4-10-membered heterocyclic group optionally substituted by one or more substituents selected from halogen, C1-6alkyl, C3-6cycloalkyl, C1-6alkoxy and C2-6alkenyl), R6 is hydrogen or C1-6alkyl, R7 is C3-6cycloalkyl, C3-6cycloalkyl-C1-6alkyl, C6-12aryl, C6-12arylC1-6alkyl or a C3-9heterocyclic group (where the alkyl, aryl heterocyclic moiety may be optionally substituted by one or more substituents selected from halogen, C1-6alkyl, C3-6cycloalkyl, C1-6alkoxy and C2-6alkenyl), X is a bond, C6-12aryl or a 5- or 6-membered heteroaryl (where the aryl or heteroaryl moiety is optionally substituted by one or more substituents selected from halogen, C1-6alkyl, C3-6cycloalkyl, C1-6alkoxy and C2-6alkenyl);
• wherein m is an integer 1, 2, 3 or 4;
• or a pharmaceutically acceptable salt or solvate thereof.