Bone morphogenetic protein (BMP)-17 and BMP-18 compositions
AssigneeGenetics Institute, Inc.
InventorsAnthony J. Celeste, Beth L. Murray
Life of this patent
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Abstract
Purified BMP-17 and BMP-18 proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-17 and BMP-18 proteins are also disclosed. The proteins may be used in the treatment of bone, cartilage, other connective tissue defects and disorders, including tendon, ligament and meniscus, in wound healing and related tissue repair, as well as for treatment of disorders and defects to tissues which include epidermis, nerve, muscle, including cardiac muscle, and other tissues and wounds, and organs such as liver, lung, epithelium, brain, spleen, cardiac, pancreas and kidney tissue. The proteins may also be useful for the induction of growth and/or differentiation of undifferentiated embryonic and stem cells.
Claims27
An isolated DNA molecule comprising a DNA sequence selected from the group consisting of:
- (a) nucleotides #1, 232, 406, 427, 751 or 796 to #1059 or 1098 of SEQ ID NO:
- 1;
- (b) nucleotides encoding amino acids #−142, −65, −7, 1, 109 or 124 to #211 or 224 of SEQ ID NO:
- 2;
- (c) nucleotides #1, 232, 406, 427, 751 or 796 to #1059 or 1098 of SEQ ID NO:
- 3;
- (d) nucleotides encoding amino acids #−135, −58, 1, 8, 116 or 131 to #218 or 231 of SEQ ID NO:
- 4;
- and
- (e) naturally occurring human allelic sequences and equivalent degenerative codon sequences of (a), (b), (c) or (d).
An isolated DNA molecule comprising a DNA sequence consisting of nucleotides #427 to #1098 of SEQ ID NO:
- 1.
An isolated DNA molecule comprising a DNA sequence consisting of nucleotides #406 to #1098 of SEQ ID NO:
- 3.
A purified bone morphogenetic protein-17 polypeptide comprising the amino acid sequence from amino acid #1 to #224 as set forth in SEQ ID NO:
- 2.
A purified bone morphogenetic protein-18 polypeptide comprising the amino acid sequence from amino acid #1 to #231 as set forth in SEQ ID NO:
- 4.
A chimeric DNA molecule comprising a DNA sequence encoding a propeptide from a member of the TGF-β superfamily of proteins linked in frame to a DNA sequence encoding a bone morphogenetic protein-17 polypeptide, said BMP-17 polypeptide comprising amino acid #1 to #224 of SEQ ID NO:
- 2.
A chimeric DNA molecule comprising a DNA sequence encoding a propeptide from a member of the TGF-β superfamily of proteins linked in frame to a DNA sequence encoding a bone morphogenetic protein-18 polypeptide, said BMP-18 polypeptide comprising amino acid #1 to #231 of SEQ ID NO:
- 4.
Dependencies are inferred from the claim text.