Novel haemopoietin receptor
OwnerDouglas James Hiltoninventor
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Abstract
The present invention relates generally to novel haemopoietin receptors, or components or parts thereof and to a method for cloning genetic sequences encoding same. More particularly, the subject invention is directed to recombinant or synthetic haemopoietin receptors or components or parts thereof. The receptor molecules or components or parts thereof and their genetic sequences of the present invention are useful in the development of a wide range of agonists, antagonists and therapeutics and diagnostic reagents based on ligand interaction with its receptor.
Claims29
(Amended) An isolated nucleic acid molecule comprising a sequence of nucleotides encoding or complementary to a sequence encoding an Interleukin (IL)-11 receptor or a mutant, derivative, component, part, fragment, homologue, analogue or a peptide or polypeptide equivalent thereof wherein said L-1 I receptor comprises an amino acid sequence as set forth in SEQ ID NO 1:
- Trp-Ser-Xaa-Trp-Ser,
- wherein Xaa is any amino acid.
(Deleted).
An isolated nucleic acid molecule comprising a sequence of DNA which encodes a mammalian IL-11 receptor α-chain, said nucleic acid molecule further defined by the ability of an oligonucleotide to hybridise thereto under medium stringency conditions and wherein said oligonucleotide is selected from SEQ ID NO:
- 6 to SEQ ID NO:
- 10 or a complement sequence thereof.
A recombinant polypeptide comprising a sequence of amino acids corresponding to all or a part of a mammalian IL-11 receptor α-chain and containing the amino acid sequence set forth in SEQ ID NO:
- 1:
- Trp-Ser-Xaa-Trp-Ser
- wherein Xaa is any amino acid.
A method of identifying and/or cloning a genetic sequence encoding or complementary to a sequence encoding a haemopoietin receptor or a component or part thereof, said method comprising screening a source of genetic material with one or more degenerate oligonucleotides designed from the sequence of amino acids comprising:
- Trp-Ser-Xaa-Trp-Ser (SEQ ID NO:
- 1)
- wherein Xaa is any amino acid.
(Amended) An oligonucleotide probe capable of hybridising under medium stringency conditions to a nucleotide sequence encoding an IL-11 receptor.
(Deleted)
Dependencies are inferred from the claim text.