Stabilized monomer adhesive compositions
AssigneeClosure Medical Corporation
InventorsBernard Malofsky, Andres Rivera, Gabriela Rueda
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Abstract
A method of sterilizing a polymerizable monomeric adhesive composition includes: providing a polymerizable monomeric adhesive composition in a container, the polymerizable monomeric adhesive composition including a polymerizable 1,1-disubstituted ethylene monomer and at least one stabilizer; holding the composition in the container for a pre-determined amount of time, which is sufficient to inhibit or eliminate polymerization of the monomer during or immediately after sterilization, before sterilizing the composition; and sterilizing the polymerizable monomeric adhesive composition inside the container.
Claims51
A polymerizable monomeric adhesive composition comprising a polymerizable 1,1-disubstituted ethylene monomer in a liquid phase and in a vapor phase, at least one vapor phase anionic stabilizer, and at least one liquid phase anionic stabilizer,
- wherein said at least one liquid phase anionic stabilizer is a strong acid and
- wherein said at least one vapor phase anionic stabilizer is at least one member selected from the group consisting of boron trifluoride and hydrogen fluoride.
A polymerizable monomeric adhesive composition comprising a polymerizable 1,1-disubstituted ethylene monomer in a liquid phase and in a vapor phase, at least one vapor phase anionic stabilizer, at least one liquid phase anionic stabilizer, and at least one free radical stabilizer,
- wherein said at least one liquid phase anionic stabilizer is a strong acid and
- wherein said at least one vapor phase anionic stabilizer is at least one member selected from the group consisting of boron trifluoride and hydrogen fluoride.
A method of making an adhesive composition comprising:
- combining a pre-formed polymerizable monomer with at least one vapor phase anionic stabilizer, at least one liquid phase anionic stabilizer, and at least one free radical stabilizer to form said adhesive composition.
Dependencies are inferred from the claim text.