Liquid formulation of metformin
AssigneeRanbaxy Laboratories Limited
InventorsRavi Chandran, Ashish Gogia
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Abstract
The present invention is directed to a liquid formulation of metformin or its pharmaceutically acceptable salts thereof. The liquid pharmaceutical composition comprises a therapeutically effective amount of metformin or its pharmaceutically acceptable salt, in a liquid carrier, which may also include a sweetener that does not increase the blood glucose level of a subject after ingestion thereof. In one embodiment, it may also include alkyl hydroxyethylcellulose, and/or a polyhydroxy alcohol. In another embodiment, the carrier may contain a sweetener, mineral acid, and bicarbonate salt maintained at a pH of 4.0 to 9.0. It is useful for treating hyperglycemia and diabetes.
Claims50
A liquid pharmaceutical composition for oral administration to a subject in need thereof which comprises a therapeutically effective amount of metformin or its pharmaceutically acceptable salt thereof in association with a pharmaceutically acceptable liquid carrier.
A liquid pharmaceutical composition which comprises a therapeutically effective amount of metformin, or its pharmaceutically acceptable salt, a sweetener that does not increase the blood glucose level of a subject after ingestion thereof, an alkyl hydroxyethylcellulose and a polyhydroxy alcohol in association with a pharmaceutically acceptable carrier, said sweetener being present in amounts ranging from about 40% to about 80% by weight, said alkyl hydroxyethylcellulose being present in amounts ranging from about 0.01% to about 5% by weight and said polyhydroxy alcohol being present in amounts ranging from about 5% to about 55% by weight.
A liquid pharmaceutical composition comprising a pharmaceutically effective amount of metformin or a salt thereof, a sweetening effective amount of a mixture of xylitol and saccharin or pharmaceutically acceptable salt thereof, and a mineral acid and bicarbonate salt, the acid and bicarbonate salt are present in an amount sufficient so that the pharmaceutical composition has a pH ranging from about 4.0 to about 9.0.
Dependencies are inferred from the claim text.