Branched chain amino acid-dependent aminotransferase inhibitors and their use in the treatment of neurodegenerative diseases

A compound of Formula I

• 41
• wherein:
• R3 is H, halogen, alkyl, carboxy, alkoxy, substituted alkoxy;
• R1, R2, R4, and R5 are independently, H, alkyl, substituted alkyl, alkoxy, substituted alkoxy, NO2, halogen, or CF3;
• R6 or R7 are independently, H, halogen, alkyl, substituted alkyl, arylalkyl, substituted arylalkyl, C(CH2)n—NHSO2-aryl, C(CH2)n—NHSO2-substituted aryl, (CH2)n—NHSO2-alkyl, (CH2)n—NHSO2-substituted alkyl, (CH2)n—NHSO2-arylalkyl, (CH2)n—NHSO2-substituted arylalkyl, NHSO2-aryl, NHSO2-substituted aryl, NHSO2-alkyl, NHSO2-substituted alkyl, NHSO2-arylalkyl, NHSO2-substituted arylalkyl, (CH2)n—aryl, (CH2)n-substituted aryl, (CH2)n-alkyl, (CH2)n-substituted alkyl, O-aryl, O-substituted aryl, O-alkyl, O-substituted alkyl, O-arylalkyl, O-substituted arylalkyl, (CH2)n—SO2NH-aryl, (CH2)n—SO2NH-substituted aryl, (CH2)n—SO2NH-alkyl, (CH2)n—SO2NH-substituted alkyl, (CH2)n—C(O)NH-arylalkyl, (CH2)n—C(O)NH-substituted arylalkyl, (CH2)n—C(O)NH-aryl, (CH2)n—C(O)NH-substituted aryl, (CH2)n—C(O)NH-alkyl, (CH2)n—C(O)NH-substituted alkyl, (CH2)n—SO2NH-arylalkyl, (CH2)n—SO2NH-substituted arylalkyl, (CH2)n—NH2, (CH2)n—NH-aryl, (CH2)n—NH-substituted aryl, (CH2)n—NH-alkyl, (CH2)n—NH-substituted alkyl, (CH2)n—NH-arylalkyl, (CH2)n—NH-substituted arylalkyl, (CH2)n—NHSO2-aryl, (CH2)n—NHSO2-substituted aryl, (CH2)n—NHSO2-alkyl, (CH2)n—NHSO2-substituted alkyl, (CH2)n—NHC(O)-arylalkyl, (CH2)n—NHC(O)-substituted arylalkyl, (CH2)n—NO2,(C≡C)-alkyl, (C≡C)-substituted alkyl, (C≡C)-arylalkyl, (C≡C)-substituted arylalkyl, (C≡C)-aryl, or (C≡C)-substituted aryl;
• and
• n is 0, 1, 2, or 3.
• or a pharmaceutically acceptable salt, ester, prodrug, or amide thereof.