(E)-4-carboxystyrl-4-chlorobenzyl sulfone and pharmaceutical compositions thereof
AssigneeTemple University of the Commonwealth System of Higher Education
InventorsStephen C. Cosenza, M. V. Ramana Reddy, E. Premkumar Reddy
Life of this patent
Estimating the term…
Abstract
Pre-treatment with α,β unsaturated aryl sulfones protects normal cells from the cytotoxic side effects of two classes of anticancer chemotherapeutics. Administration of a cytoprotective sulfone compound to a patient prior to anticancer chemotherapy with a mitotic phase cell cycle inhibitor or topoisomerase inhibitor reduces or eliminates the cytotoxic side effects of the anticancer agent on normal cells. The cytoprotective effect of the α,β unsaturated aryl sulfone allows the clinician to safely increasing the dosage of the anticancer chemotherapeutic.
Claims2
(E)-4-carboxystyryl-4-chlorobenzyl sulfone, or pharmaceutically acceptable salt thereof:
A composition comprising:
- (E)-4-carboxystyryl-4-chlorobenzyl sulfone, or pharmaceutically acceptable salt thereof;
- and
- a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.