Cancer chemopreventative compounds and compositions and methods of treating cancers
OwnerJohn M. Pezzuto, James D. McChesney +2inventors
InventorsJohn M. Pezzuto, James D. McChesney, Muriel Anne Cuendet, Lawrence Helson
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Abstract
A composition and method of treating multiple myeloma are disclosed. The composition and method utilize brusatol, bruceantin, glaucarubolone, and derivatives thereof as active multiple myeloma treating agents in mammals, including humans.
Claims29
A method of treating multiple myeloma comprising administering a pharmaceutical composition to a mammal in need thereof, in a sufficient amount to suppress the initiation, promotion, or progression of the multiple myeloma, said composition comprising an active agent selected from the group consisting of brusatol, bruceantin, glaucarubolone, and derivatives thereof.
A method of treating multiple myeloma comprising administering a therapeutically effective amount of an active ingredient to an individual in need thereof, to suppress the initiation, promotion, or progression of the multiple myeloma, said active agent capable of modulating c-Myc or related oncogenes or transcriptase factors.
A method of treating a multiple myeloma comprising administering a therapeutically effective amount of an active ingredient to an individual in need thereof, to stimulate differentiation of cancer cells thereby suppressing the initiation, promotion, or progression of the cancer, said active agent capable of modulating c—Myc or related oncogenes or transcription factors.
A method of treating a multiple myeloma comprising administering a therapeutically effective amount of an active quassinoid derivative to an individual in need thereof, to stimulate differentiation of multiple myeloma cells thereby suppressing the initiation, promotion, or progression of the cancer, the said active quassinoid derivative capable of modulating c-Myc or related oncogenes or transcription factors.
Dependencies are inferred from the claim text.