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US 2003/0149089 A1Published application
Antibacterial compounds
AssigneeSmithKline Beecham Corporation
InventorsDirk Heerding, Kenneth A. Newlander
Life of this patent
Estimating the term…
Abstract
Compounds of formula (I) and formula (II) are disclosed which are useful in the treatment bacterial infections: 1 wherein: R1 is C1-4alkyl, Ar or 2-thienyl or 3-thienyl; R2 is C1-4alkyl or Ar; and n is 0-3; or a pharmaceutically acceptable salt thereof.
Claims20
A compound according to formula (I) or formula (II):
- 15
- wherein:
- R1 is C1-4alkyl, Ar or 2-thienyl or 3-thienyl;
- R2 is C1-4alkyl or Ar;
- and
- n is 0-3;
- or a pharmaceutically acceptable salt thereof.
4 more elements
A method for inhibiting Fab I which comprises administering to a subject in need thereof a compound which is:
- 1-Benzyl-4-(2-thienyl)-1H-imidazole;
- 1-Benzyl-4-(3-thienyl)-1H-imidazole;
- 1-Benzyl-4-(4-methoxyphenyl)-1H-imidazole;
- 1-(4-Methylbenzyl)-4-(3-thienyl)-1H-imidazole;
- 4-(4-Methoxyphenyl)-1-(4-methylbenzyl)-1H-imidazole;
- 1-(4-Chlorobenzyl)-4-(2-thienyl)-1H-imidazole;
- 1-(4-Chlorobenzyl)-4-(3-thienyl)-1H-imidazole;
- 1-(4-Chlorobenzyl)-4-(4-methoxyphenyl)-1H-imidazole;
- 1-(3,4-Dichlorobenzyl)-4-(2-thienyl)-1H-imidazole;
- 1-(3,4-Dichlorobenzyl)-4-[4-(trifluoromethyl)phenyl]-1H-imidazole;
- 1-(3,4-Dichlorobenzyl)-4-phenyl-1H-imidazole;
- 1-(4-Methoxybenzyl)-4-(3-thienyl)-1H-imidazole;
- 1-(4-Methoxybenzyl)-4-(4-methoxyphenyl)-1H-imidazole;
- 1-Benzo[1,3]dioxol-5-ylmethyl-4-thiophen-3-yl-1H-imidazole;
- 4-(2-Methoxy-phenyl)-1-naphthalen-2-ylmethyl-1H-imidazole;
- 1-(2,4-Dichloro-benzyl)-4-thiophen-3-yl-1H-imidazole;
- 4-Thiophen-3-yl-1-(3-m-tolyl-propyl)-1H-imidazole;
- 1-[3-(4-Methoxy-phenyl)-propyl]-4-thiophen-3-yl-1H-imidazole;
- 4-Thiophen-3-yl-1-[3-(3-trifluoromethyl-phenyl)-propyl]-1H-imidazole;
- 1-(4-Isopropyl-benzyl)-4-thiophen-3-yl-1H-imidazole;
- 1-[3-(3-Methoxy-phenyl)-propyl]-4-thiophen-3-yl-1H-imidazole;
- 1-(4-Ethyl-benzyl)-4-thiophen-3-yl-1H-imidazole;
- 1-(4-Methylbenzyl)-4-phenyl-1H-imidazole;
- or
- 1-(4-Methylbenzyl)-4-(2-thienyl)-1H-imidazole;
- or a pharmaceutically acceptable salt thereof.
23 more elements
The use of a compound which is:
- 1-Benzyl-4-(2-thienyl)-1H-imidazole;
- 1-Benzyl-4-(3-thienyl)-1H-imidazole;
- 1-Benzyl-4-(4-methoxyphenyl)-1H-imidazole;
- 1-(4-Methylbenzyl)-4-(3-thienyl)-1H-imidazole;
- 4-(4-Methoxyphenyl)-1-(4-methylbenzyl)-1H-imidazole;
- 1-(4-Chlorobenzyl)-4-(2-thienyl)-1H-imidazole;
- 1-(4-Chlorobenzyl)-4-(3-thienyl)-1H-imidazole;
- 1-(4-Chlorobenzyl)-4-(4-methoxyphenyl)-1H-imidazole;
- 1-(3,4-Dichlorobenzyl)-4-(2-thienyl)-1H-imidazole;
- 1-(3,4-Dichlorobenzyl)-4-[4-(trifluoromethyl)phenyl]-1H-imidazole;
- 1-(3,4-Dichlorobenzyl)-4-phenyl-1H-imidazole;
- 1-(4-Methoxybenzyl)-4-(3-thienyl)-1H-imidazole;
- 1-(4-Methoxybenzyl)-4-(4-methoxyphenyl )-1H-imidazole;
- 1-Benzo[1,3]dioxol-5-ylmethyl-4-thiophen-3-yl-1H-imidazole;
- 4-(2-Methoxy-phenyl)-1-naphthalen-2-ylmethyl-1H-imidazole;
- 1-(2,4-Dichloro-benzyl)-4-thiophen-3-yl-1H-imidazole;
- 4-Thiophen-3-yl-1-(3-m-tolyl-propyl)-1H-imidazole;
- 1-[3-(4-Methoxy-phenyl)-propyl]-4-thiophen-3-yl-1H-imidazole;
- 4-Thiophen-3-yl-1-[3-(3-trifluoromethyl-phenyl)-propyl]-1H-imidazole;
- 1-(4-Isopropyl-benzyl)-4-thiophen-3-yl-1H-imidazole;
- 1-[3-(3-Methoxy-phenyl)-propyl]-4-thiophen-3-yl-1H-imidazole;
- 1-(4-Ethyl-benzyl)-4-thiophen-3-yl-1H-imidazole;
- 1-(4-Methylbenzyl)-4-phenyl-1H-imidazole;
- or
- 1-(4-Methylbenzyl)-4-(2-thienyl)-1H-imidazole
- in the manufacture of a medicament for the treatment of diseases in which inhibition of Fab I is indicated.
23 more elements
Dependencies are inferred from the claim text.