HIV treatment
AssigneeUniversity of Arizona Foundation
InventorJames Berger Camden
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AssigneeUniversity of Arizona Foundation
InventorJames Berger Camden
Estimating the term…
A pharmaceutical composition that can be used to treat HIV is disclosed. The composition comprising an effective amount of a benzimidazole of the formula: 1 wherein X is hydrogen, halogen, nitro, oxychloro alkyl of less than 7 carbon atoms or alkoxy of less than 7 carbon atoms; n is a positive integer of 4 or less; and R is hydrogen, alkylcarbamoyl wherein the alkyl group has less than 7 carbon atoms, or an alkyl group having from 1 to 8 carbon atoms, and R2 is NHCOOR, wherein R1, is an aliphatic hydrocarbon of less than 7 carbon atoms. The pharmaceutically acceptable organic or inorganic addition salts thereof are also used herein. The preferred compounds are methyl-(butylcarbamoyl)-2-benzimidazolecarbamate and 2-methoxycarbonylaminobenzimidazole. In the present invention it has been discovered that the compounds described above are useful for treattment of HIV infection when used alone or in combination with other anti-viral agents.
A pharmaceutical composition comprising a therapeutically effective amount of:
A method of treating HIV comprising administering therapeutically effective amount of a benzimidazole of the formula:
A method of treating HIV infections comprising administering a therapeutically effective amount of an adjunct therapy in combination with a benzimidazole of the formula:
A method according to claim 17 wherein said adjunct therapy comprises a member selected from the group consisting of AZT, TC-3, protease inhibitors, thiabendazole, N-chlorophenylcarbamates, N-chlorophenylthiocarbamates or (5-aryl-1,2,4-thiadiazolyl)-thioreas.
Dependencies are inferred from the claim text.