NR1H4 nuclear receptor binding compounds

A compound including resolved diastereoisomers and enantiomers, and tautomers, pharmaceutical acceptable salts or solvates thereof, having the following formula (1):

• 31
• wherein:
• R1 is C1 to C7 alkyl, C1 to C7 substituted alkyl, phenyl, substituted phenyl, alkylphenyl, substituted alkylphenyl, C2 to C7 heterocyclic ring, C2 to C7 substituted heterocyclic ring, C5 to C6 heteroaryl, and C5 to C6 substituted heteroaryl;
• R2 is C1 to C7 alkyl, C1 to C7 substituted alkyl, phenyl, substituted phenyl, alkylphenyl, substituted alkylphenyl, C2 to C7 heterocyclic ring, C2 to C7 substituted heterocyclic ring, C5 to C6 heteroaryl, and C5 to C6 substituted heteroaryl.
• R3 is hydrogen, C1 to C8 alkyl, C1 to C8 substituted alkyl, C7 to C1-2 alkylphenyl, C7 to C12 substituted alkylphenyl, naphthyl, substituted naphthyl, C1 to C8 alkanesulfonyl, benzenesulfonyl, substituted benzenesulfonyl, and C1 to C8 substituted acyl;
• R4 is hydrogen, C1 to C8 alkyl, C1 to C8 substituted alkyl, C7 to C1-2 alkylphenyl, C7 to C12 substituted alkylphenyl, naphthyl, substituted naphthyl, C1 to C8 alkanesulfonyl, benzenesulfonyl, substituted benzenesulfonyl, C1 to C8 substituted acyl;
• where R3 and R4 may be taken together with nitrogen to form a heterocycle or substituted heterocycle.