Pyrrolidinone derivatives

A pharmaceutical composition comprising a compound according to formula I

• 3
• wherein,
• Y is oxygen or sulfur;
• G and G′, together with the bond linking them, are HC—CH or C═C;
• V is aryl, heterocycle or cycloalkyl;
• Z is halogen, alkyl, alkenyl, alkynyl, hydroxyl, amino, alkoxy, aryloxy, nitro or cyano;
• R1 is hydrogen, halogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl or heterocycle;
• R2 is hydrogen or hydroxy;
• R3 is —C(O)R3a, —C(O)OR3a, —C(O)N(R3a)(R3b), —S(O)2R3a, —S(O)R3a or —SR3a wherein R3a and R3b have independently the same meaning as R1;
• R4 is hydroxy, sulfanyl or amino;
• t is 0, 1, 2, 3, 4 or 5;
• or a pharmaceutically acceptable salt or metabolically cleavable derivative thereof, together with a pharmaceutically acceptable diluent or carrier.