Cycloalkano-indole and -azaindole derivatives

Cycloalkano-indole and -azaindole derivatives of the general formula (I)

• 349
• in which
• R1 and R2, including the double bond connecting them, together form a phenyl or pyridyl ring or a ring of the formula
• 350
• wherein
• R8 denotes hydrogen or straight-chain or branched alkyl having up to 4 carbon atoms,
• R3 and R4, including the double bond connecting them, together form a phenyl ring or a 4- to 8-membered cycloalkene or oxocycloalkene radical,
• or ring systems mentioned under R1/R2 and R3/R4 optionally being substituted up to 3 times by identical or different halogen, trifluoromethyl, carboxyl or hydroxyl substituents, by straight-chain or branched alkoxy or alkoxycarbonyl each having up to 6 carbon atoms or by straight-chain or branched alkyl having up to 6 carbon atoms, which, for its part, can be substituted by hydroxyl or by straight-chain or branched alkoxy having up to 4 carbon atoms,
• D represents hydrogen, cycloalkyl having 4 to 12 carbon atoms or straight-chain or branched alkyl having up to 12 carbon atoms,
• E represents the —CO— or —CS— group,
• L represents an oxygen or sulphur atom or a group of the formula —NR9,
• wherein
• R9 denotes hydrogen or straight-chain or branched alkyl having up to 6 carbon atoms, which is optionally substituted by hydroxyl or phenyl,
• R5 represents phenyl or a 5- to 7-membered saturated or unsaturated heterocycle having up to 3 heteroatoms from the series consisting of S, N and/or O,
• the cycles optionally being substituted up to 3 times by identical or different nitro, carboxyl, halogen or cyano substituents or by straight-chain or branched alkenyl or alkoxycarbonyl each having up to 6 carbon atoms or by straight-chain or branched alkyl having up to 6 carbon atoms, which is optionally substituted by hydroxyl, carboxyl or by straight-chain or branched alkoxy or alkoxycarbonyl each having up to 6 carbon atoms,
• and/or the cycles optionally being substituted by a group of the formula —OR10 or —NR11R12,
• wherein
• R10 denotes hydrogen or straight-chain or branched alkyl or alkenyl each having up to 6 carbon atoms,
• R11 and R12 are identical or different and denote phenyl, hydrogen or straight-chain or branched alkyl having up to 6 carbon atoms or straight-chain or branched acyl having up to 8 carbon atoms, which is optionally substituted by a group of the formula —NR13R14,
• wherein
• R13 and R14 are identical or different and denote hydrogen or straight-chain or branched acyl having up to 8 carbon atoms,
• R6 represents hydrogen, carboxyl or straight-chain or branched alkoxycarbonyl having up to 5 carbon atoms,
• or represents straight-chain or branched alkyl having up to 6 carbon atoms, which is optionally substituted by hydroxyl or by a group of the formula —O—CO—R15,
• wherein
• R15 denotes phenyl which is optionally substituted up to 3 times by identical or different halogen or hydroxyl substituents or by straight-chain or branched alkyl having up to 5 carbon atoms, or straight-chain or branched alkyl or alkenyl each having up to 22 carbon atoms, each of which is optionally substituted by a group of the formula —OR16,
• wherein
• R16 is hydrogen, benzyl, triphenylmethyl or straight-chain or branched acyl having up to 6 carbon atoms,
• R7 represents hydrogen or
• R6 and R7 together represent the group of the formula ═O, if appropriate in an isomeric form, and their salts.