Methods for synthesizing heterocycles and therapeutic use of the heterocycles for cancers

A compound having formula A ##STR1## wherein:

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• wherein,
• R1, R2, R3, R4, R5, R6, R7, R8, and R9 are each independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, heterocycloalkylaryl, heteroaryl, acyl, acylalkyl, carboxy, carboxamido, trialkylsilyl, aryldialkyl, hydroxy, alkoxy, aryloxy, heteroaryloxy, chloro, bromo, fluoro, iodo, thio, alkylthio, arylthio, acyclthio, amino, alkylamino, dialkylamino, acylamino, arylamino, diarylamino, carboxamido;
• the number n ranges from 0 to 4;
• the X can be —O—, —S—, —S(O)—, —S(O2)-, —CH2-, —NR10- where R10 is selected from the group consisting of hydrogen, alkyl, cycloalkyl, heterocycloalkylaryl, heteroaryl, acyl, acylalkyl, carboxy, carboxamido, trialkylsilyl, aryldialkyl group.