Process for preparing crystalline from I of cabergoline
AssigneePharmacia Italia S.p.A.
InventorsAttilio Tomasi, Stefania Magenes, Mario Ungari, Giuliano Ramella, Gianfranco Pallanza
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Abstract
A process for producing crystalline form I of cabergoline, which process comprises crystallization of the desired form from a toluene/diethyl ether mixture comprising raw cabergoline, followed by recovery and drying of the resulting crystals. A new solvate form V of cabergoline, useful as an intermediate, is also provided.
Claims9
A process for producing cabergoline Form I, which process comprises crystallisation of the desired crystalline form from a toluene/diethyl ether mixture comprising raw cabergoline, followed by recovery and drying of the resulting crystals.
Solvate form V of cabergoline having the XRD powder pattern of FIG. 5.
A process according to claim 9 in which the toluene/ diethyl ether mixture is a 1:1 mixture.
Dependencies are inferred from the claim text.