Substituted quinolinecarboxamides as antiviral agents

A compound of claim I

• 45
• or a pharmaceutically acceptable salt thereof wherein
• X is Cl, Br, CN, NO2, or F;
• Y is morpholinylmethyl, tetrahydro-2H-pyranylmethyl, hydroxypropynyl, or hydroxypropyl;
• Z is het1, or C1-7 alkyl optionally substituted with at least one halo, NR1R2, OR3, or het2;
• R1 and R2 are independently H, C1-7 alkyl, or C2-7alkyl substituted with at least one OH;
• R3 is H, or C1-7alkyl;
• het1 is a five- (5), or six- (6) membered saturated or unsaturated heterocyclic ring bonded via a carbon atom having 1, 2, or 3 heteroatoms selected from the group consisting of oxygen, sulfur, or nitrogen, wherein the het is optionally fused to a benzene ring, and optionally substituted with one or more substituents selected from the group consisting of halo, OR3, CN, phenyl, CO2R3, CF3, or C1-6 alkyl which may be further substituted by one to three SR3, NR3R3, OR3, or CO2R3 groups;
• and het2 is a five- (5), or six- (6) membered saturated or unsaturated heterocyclic ring having 1, 2, or 3 heteroatoms selected from the group consisting of oxygen, sulfur, or nitrogen, wherein het is optionally fused to a benzene ring, and optionally substituted with one or more substituents selected from the group consisting of halo, OR3, CN, phenyl, CO2R3, CF3, oxo, oxime, or C1-6 alkyl which may be further substituted by one to three SR3, NR3R3, OR3, or CO2R3 groups.