Indazoles substituted with1,1-dioxoisothiazolidine useful as inhibitors of cell proliferation

A compound represented by the following formula (1):

• 21
• in which
• n represents 0, 1, 2 or 3,
• X represents oxygen, sulfur or nitrogen atom,
• R1 and R2 each independently represent hydrogen, amino, hydroxy, lower alkyl or cycloalkyl, or together form cycloalkyl,
• R3 represents hydrogen;
• lower alkyl;
• phenyl or naphthyl which may be unsubstituted or substituted with one to three substituents selected from the group consisting of hydroxy, halogen, nitro, amide, ester, carboxy, cyano, amidinyl, —O—R5, —NR6R7, phenyl, alkylsulfanyl, R8—SO2—, lower alkyl, lower alkyl substituted with R9, pyridinyl, piperidinyl, morpholinyl, piperazinyl, thienyl and furyl;
• aromatic and bicyclic aromatic compounds bearing at least one heteroatom selected from nitrogen, oxygen or sulfur atom;
• C3-7-cycloalkyl bearing at least one heteroatom selected from nitrogen, oxygen or sulfur atom;
• piperazinyl, imidazolyl, morpholinyl or piperidinyl which may be unsubstituted or substituted with one or two substituents selected from the group consisting of lower alkyl, phenyl, phenyl substituted with halogen, phenyl substituted with alkoxy, phenyl substituted with alkylcarbonyl, biphenyl and naphthyl;
• thiazole which may be unsubstituted or substituted with amino, mono- or di-lower alkylamino, alkylcarbonylamino, benzylamino, benzyloxycarbonylamino, benzyloxybenzylamino or alkoxycarbonylamino;
• benzodioxol;
• isoquinoline;
• indolyl;
• or benzimidazole wherein R5 represents phenyl, benzyl, lower alkyl, alkoxyalkyl, alkoxyalkoxylalkyl, alkoxyalkoxyalkoxyalkyl, aminoalkyl or mono- or di-alkylaminoalkyl, R6 and R7 are identifical or different from each other and represent hydrogen, lower alkyl, oxygen or benzyl, or joined to form a ring, and R8 and R9 represent each independently lower alkyl, amino, morpholinyl, piperazinyl, N-alkylpiperazinyl or imidazole, and
• R4 represents nothing when X is oxygen or sulfur atom, but represents hydroxy or alkoxy when X is nitrogen atom,
• pharmaceutically acceptable salt, solvated product or isomer thereof.